abstract：:The impact of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae of food animal origins on human health has caught considerable attention worldwide. Intestinal Escherichia coli obtained from healthy food animals (pigs, cattle and poultry) in China were tested for the presence of ESBL genes. CTX-M-produc...

journal_title：International journal of antimicrobial agents

authors： Zheng H,Zeng Z,Chen S,Liu Y,Yao Q,Deng Y,Chen X,Lv L,Zhuo C,Chen Z,Liu JH

更新日期：2012-04-01 00:00:00

abstract：:Fifteen carbapenem-non-susceptible Escherichia coli isolates obtained during the period May 2010 to April 2011 in a hospital and a long-term care facility (LTCF) in Larissa (Central Greece) were investigated. Minimum inhibitory concentrations (MICs) to various antimicrobial agents were determined by Etest. Carriage of...

journal_title：International journal of antimicrobial agents

authors： Mavroidi A,Miriagou V,Malli E,Stefos A,Dalekos GN,Tzouvelekis LS,Petinaki E

更新日期：2012-03-01 00:00:00

abstract：:The bactericidal activity and resistance selectivity of garenoxacin against Streptococcus pneumoniae with mutations in ParC (S79F) or both GyrA (S81F) and ParC (D83Y and K137N) were investigated using in vitro pharmacokinetic models simulating plasma concentrations for a standard clinical regimen [400mg once daily (q....

journal_title：International journal of antimicrobial agents

authors： Fukuda Y,Takahata M,Sugiura Y,Shinmura Y,Nomura N

更新日期：2012-02-01 00:00:00

abstract：:Use of rifampicin (RIF) in combination with colistin (COL) has been proposed for the treatment of multidrug-resistant Acinetobacter baumannii infections owing to in vitro synergism. The aim of the present study was to evaluate the molecular epidemiology and mechanisms of RIF resistance in 57 clinical isolates of A. ba...

journal_title：International journal of antimicrobial agents

authors： Giannouli M,Di Popolo A,Durante-Mangoni E,Bernardo M,Cuccurullo S,Amato G,Tripodi MF,Triassi M,Utili R,Zarrilli R

更新日期：2012-01-01 00:00:00

abstract：:The main objectives in childhood urinary tract infections are rapid recovery from complaints, prevention of urosepsis and infection-related complications as well as the prevention of renal parenchymal damage. Calculated antibiotic therapy should take the local resistance rates of uropathogens into consideration. The c...

journal_title：International journal of antimicrobial agents

authors： Beetz R,Westenfelder M

更新日期：2011-12-01 00:00:00

abstract：:In the present work, the antiviral activity of brequinar (BQR) against the replication of Cantagalo virus was evaluated. BQR is a potent inhibitor of cellular dihydroorotate dehydrogenase, an enzyme of the de novo pyrimidine biosynthetic pathway. Infection in the presence of 0.5μM BQR reduced virus progeny production ...

journal_title：International journal of antimicrobial agents

authors： Schnellrath LC,Damaso CR

更新日期：2011-11-01 00:00:00

abstract：:Gentamicin-containing polymethylmethacrylate (PMMA) beads are frequently used to prevent and treat orthopaedic infections. The beads are typically inserted to fill anatomical defects secondary to surgical debridement. Local gentamicin use results in low serum levels whilst achieving high concentrations at the site of ...

journal_title：International journal of antimicrobial agents

authors： Barth RE,Vogely HC,Hoepelman AI,Peters EJ

更新日期：2011-11-01 00:00:00

abstract：:Stenotrophomonas maltophilia and Acinetobacter baumannii are recognised as important nosocomial pathogens; however, due to their intrinsic resistance to multiple antibiotics, treatment options are limited. Polyphenols from black tea have been shown to possess antibacterial action. In this study, the antibacterial effe...

journal_title：International journal of antimicrobial agents

authors： Betts JW,Kelly SM,Haswell SJ

更新日期：2011-11-01 00:00:00

abstract：:Controversy continues regarding whether the presence of meticillin resistance increases mortality risk in Staphylococcus aureus infections. In this study, we assessed the role of meticillin resistance in survival of patients with S. aureus infection included in the EPIC II point-prevalence study of infection in critic...

journal_title：International journal of antimicrobial agents

authors： Hanberger H,Walther S,Leone M,Barie PS,Rello J,Lipman J,Marshall JC,Anzueto A,Sakr Y,Pickkers P,Felleiter P,Engoren M,Vincent JL,EPIC II Group of Investigators.

更新日期：2011-10-01 00:00:00

abstract：:Antimicrobial susceptibility testing plays a key role in clinical microbiology. The disk diffusion test dates back to the 1940s and became standardised from the 1950s, with the International Collaborative Study (ICS) and National Committee for Clinical Laboratory Standards (NCCLS) as the two major standards. Interlabo...

journal_title：International journal of antimicrobial agents

authors： Kronvall G,Giske CG,Kahlmeter G

更新日期：2011-10-01 00:00:00

abstract：:In this study, the in vitro activity of tigecycline against 1140 enterococci collected from humans, food products, animals and the environment in Portugal (1996-2008) was analysed. Ten isolates (seven Enterococcus faecalis and three Enterococcus spp.) non-susceptible to tigecycline (minimum inhibitory concentrations o...

journal_title：International journal of antimicrobial agents

authors： Freitas AR,Novais C,Correia R,Monteiro M,Coque TM,Peixe L

更新日期：2011-08-01 00:00:00

abstract：:The characteristics of 218 Klebsiella pneumoniae isolates from patients with hospital-acquired pneumonia in nine Asian countries were investigated. In total, 92 isolates (42.2%) produced extended-spectrum β-lactamases (ESBLs), amongst which 67 (72.8%) possessed CTX-M ESBL genes; CTX-M-15 was the major ESBL (55 isolate...

journal_title：International journal of antimicrobial agents

authors： Lee MY,Ko KS,Kang CI,Chung DR,Peck KR,Song JH

更新日期：2011-08-01 00:00:00

abstract：:In 2008, the Scottish Management of Antimicrobial Resistance Action Plan (ScotMARAP) was published by the Scottish Government. One of the key actions was initiation of the Scottish Antimicrobial Prescribing Group (SAPG), hosted within the Scottish Medicines Consortium, to take forward national implementation of the ke...

journal_title：International journal of antimicrobial agents

authors： Nathwani D,Sneddon J,Malcolm W,Wiuff C,Patton A,Hurding S,Eastaway A,Seaton RA,Watson E,Gillies E,Davey P,Bennie M,Scottish Antimicrobial Prescribing Group.

更新日期：2011-07-01 00:00:00

abstract：:The aim of this study was to determine the rifampicin (RIF) resistance rate of meticillin-resistant Staphylococcus aureus (MRSA) amongst patients with MRSA bacteraemia who have or have not been exposed to RIF-containing antituberculous (anti-TB) treatment. From 2000 to 2008, patients with MRSA bacteraemia and previous...

journal_title：International journal of antimicrobial agents

authors： Tan CK,Lai CC,Liao CH,Lin SH,Huang YT,Hsueh PR

更新日期：2011-06-01 00:00:00

abstract：:In this study, 183 Salmonella enterica isolates were characterised for integrons and virulence genes. Among the isolates, 46% were positive for intI1, but no isolates carried intI2 or intI3. Eighteen class 1 integrons (21%) contained resistance gene cassettes (i.e. dfrA1-orfC, dfrA12-aadA2, bla(PSE-1) and aadA2) and f...

journal_title：International journal of antimicrobial agents

authors： Wannaprasat W,Padungtod P,Chuanchuen R

更新日期：2011-05-01 00:00:00

abstract：:Acinetobacter baumannii has emerged as a major pathogen causing nosocomial infections, particularly in critical patients admitted to the Intensive Care Unit. Increasing resistance to carbapenems in A. baumannii has been observed worldwide. Here we report the clinical impact and mechanism of imipenem heteroresistance (...

journal_title：International journal of antimicrobial agents

authors： Lee HY,Chen CL,Wang SB,Su LH,Chen SH,Liu SY,Wu TL,Lin TY,Chiu CH

更新日期：2011-04-01 00:00:00

abstract：:To characterise the prevalence of β-lactamases and 16S rRNA methylase genes amongst clinical Klebsiella pneumoniae isolates carrying plasmid-mediated quinolone resistance (PMQR) determinants in China, 59 non-duplicate K. pneumoniae isolates harbouring at least one PMQR gene were screened for common β-lactamases and 16...

journal_title：International journal of antimicrobial agents

authors： Luo Y,Yang J,Zhang Y,Ye L,Wang L,Guo L

更新日期：2011-04-01 00:00:00

abstract：:With an ageing and ever more obese population, chronic wounds such as diabetic ulcers, pressure ulcers and venous leg ulcers are an increasingly relevant medical concern. Identification of bacterial biofilm contamination as a major contributor to non-healing wounds demands biofilm-targeted strategies to manage chronic...

journal_title：International journal of antimicrobial agents

authors： Ammons MC,Ward LS,Dowd S,James GA

更新日期：2011-04-01 00:00:00

abstract：:In this study, the antimicrobial susceptibilities and prevalence of plasmid-mediated quinolone resistance determinants amongst Salmonella enterica serotype Typhimurium isolates from hospitalised paediatric patients with diarrhoea in China were investigated. In total, 40 (64.5%) of 62 S. Typhimurium isolates were resis...

journal_title：International journal of antimicrobial agents

authors： Yu F,Chen Q,Yu X,Pan J,Li Q,Yang L,Chen C,Zhuo C,Li X,Zhang X,Huang J,Wang L

更新日期：2011-02-01 00:00:00

abstract：:The proline-rich antimicrobial peptide oncocin is remarkably active in vitro against a number of important Gram-negative bacteria of concern to humans owing to their increasing resistance to antibiotics, i.e. Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae) and non-fermenting speci...

journal_title：International journal of antimicrobial agents

authors： Knappe D,Kabankov N,Hoffmann R

更新日期：2011-02-01 00:00:00

abstract：:Using a murine model of disseminated infection by Fusarium verticillioides, the efficacy of liposomal amphotericin (L-AmB) B at 10mg/kg body weight once daily and terbinafine (TRB) at 150 mg/kg body weight twice daily, alone and in combination, was evaluated. The combination of L-AmB with TRB was the only treatment ab...

journal_title：International journal of antimicrobial agents

authors： Ruíz-Cendoya M,Pastor FJ,Capilla J,Guarro J

更新日期：2011-01-01 00:00:00

abstract：:The objective of this study was to evaluate the steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients requiring antimicrobial therapy. Nine patients received 1g every 8h (q8h), infused over 4h, and steady-state pharmacokinetic parameters were determi...

journal_title：International journal of antimicrobial agents

authors： Cheatham SC,Shea KM,Healy DP,Humphrey ML,Fleming MR,Wack MF,Smith DW,Sowinski KM,Kays MB

更新日期：2011-01-01 00:00:00

abstract：:Dental caries and periodontitis are common oral bacterial infectious diseases. Their prevention and treatment requires control of the causative pathogens, such as Streptococcus mutans and Porphyromonas gingivalis, that exist within dental plaque. As one of the attractive future substitutes for conventional antibiotics...

journal_title：International journal of antimicrobial agents

authors： Liu Y,Wang L,Zhou X,Hu S,Zhang S,Wu H

更新日期：2011-01-01 00:00:00

abstract：:The use of biomarkers might help to avoid antibiotic misuse and overuse and to curb the rising incidence of microbial resistance. Amongst >100 biomarkers proposed for use as infection/sepsis markers, procalcitonin is the most frequently evaluated. It has been tested in 11 randomised controlled trials with more than 35...

journal_title：International journal of antimicrobial agents

authors： Reinhart K,Hartog CS

更新日期：2010-12-01 00:00:00

abstract：:Oritavancin is a lipoglycopeptide antibiotic under investigation for the treatment of serious infections caused by Gram-positive bacteria. Oritavancin has demonstrated rapid dose-dependent bactericidal activity towards vancomycin-susceptible and -resistant enterococci, meticillin-susceptible and -resistant Staphylococ...

journal_title：International journal of antimicrobial agents

authors： Bouza E,Burillo A

更新日期：2010-11-01 00:00:00

abstract：:No vaccine exists against any form of leishmaniasis. Because recovery from infection is usually accompanied by a strong immunity and because it is possible to protect experimental animals against live challenge, hope for the development of a vaccine for humans has been high. However, leishmaniasis is a disease of the ...

journal_title：International journal of antimicrobial agents

authors： Modabber F

更新日期：2010-11-01 00:00:00

abstract：:The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants. In particular, the media attenti...

journal_title：International journal of antimicrobial agents

authors： Walsh TR

更新日期：2010-11-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are essential host defence molecules found in a wide variety of species and are promising antibacterial therapeutic candidates. Focusing on the human cathelicidin peptide LL-37, the aim of the present study was to explore the mechanisms of action and antimicrobial activities of a library ...

journal_title：International journal of antimicrobial agents

authors： Kanthawong S,Bolscher JG,Veerman EC,van Marle J,Nazmi K,Wongratanacheewin S,Taweechaisupapong S

更新日期：2010-11-01 00:00:00

abstract：:The global spread of dengue fever within and beyond the usual tropical boundaries threatens a large percentage of the world's population, as human and environmental conditions for persistence and even spread are present in all continents. The disease causes great human suffering, a sizable mortality from dengue haemor...

journal_title：International journal of antimicrobial agents

authors： Guzman A,Istúriz RE

更新日期：2010-11-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are produced by all forms of living organisms and represent a novel class of antibiotics to treat infectious diseases. In this study, 29 AMPs of varying length and characteristics were synthesised chemically and were evaluated for their ability to inhibit the growth of Bacillus globigii, ...

journal_title：International journal of antimicrobial agents

authors： Dawson RM,McAllister J,Liu CQ

更新日期：2010-10-01 00:00:00

abstract：:The activity of telavancin was evaluated against Staphylococcus spp. collected from European hospitals as part of an international surveillance study (2007-2008). A total of 7534 staphylococcal clinical isolates [5726 Staphylococcus aureus and 1808 coagulase-negative staphylococci (CoNS)] were included. Isolates were ...

journal_title：International journal of antimicrobial agents

authors： Mendes RE,Sader HS,Jones RN

更新日期：2010-10-01 00:00:00

abstract：:Coxiella burnetii is the bacterial agent of Q fever in humans. Acute Q fever generally manifests as a flu-like illness and is typically self-resolving. In contrast, chronic Q fever usually presents with endocarditis and is often life-threatening without appropriate antimicrobial therapy. Unfortunately, available optio...

journal_title：International journal of antimicrobial agents

authors： Minnick MF,Hicks LD,Battisti JM,Raghavan R

更新日期：2010-10-01 00:00:00

abstract：:The objective of this study was to determine whether exposure of Staphylococcus aureus to early (ciprofloxacin or levofloxacin) and a recent fluoroquinolone (moxifloxacin) has differential potential as a mutator or selector for meticillin resistance. The potential of fluoroquinolones to act as mutators or selectors wa...

journal_title：International journal of antimicrobial agents

authors： Dalhoff A,Schubert S

更新日期：2010-09-01 00:00:00

abstract：:Wide-spectrum quinolones such as moxifloxacin and levofloxacin as well as high-order cephalosporins such as cefoperazone and cefepime have increased antimicrobial activity. However, little is known about their distribution in fetal blood. Therefore, the aim of this study was to measure and compare maternal and fetal b...

journal_title：International journal of antimicrobial agents

authors： Ozyuncu O,Nemutlu E,Katlan D,Kir S,Beksac MS

更新日期：2010-08-01 00:00:00

abstract：:In this study, we investigated the in vivo efficacy of anidulafungin during the early phase of disseminated candidiasis in a neutropenic murine model and compared the results with those obtained for fluconazole. Antifungal efficacy was evaluated by reduction of fungal burden in the tissues of infected animals at perio...

journal_title：International journal of antimicrobial agents

authors： Krishnan-Natesan S,Manavathu EK,Cutright JL,Chandrasekar PH

更新日期：2010-07-01 00:00:00

abstract：:Visceral leishmaniasis (VL), caused by the protozoan Leishmania sp., affects 500000 people annually, with the Indian subcontinent contributing a significant proportion of these cases. Emerging refractoriness to conventional antimony therapy has emphasised the need for safer yet effective antileishmanial drugs. Artemis...

journal_title：International journal of antimicrobial agents

authors： Sen R,Ganguly S,Saha P,Chatterjee M

更新日期：2010-07-01 00:00:00

abstract：:New treatments are urgently required for infections caused by meticillin-resistant Staphylococcus aureus (MRSA) as these strains are often resistant to multiple conventional antibiotics. Earlier studies showed that ranalexin, an antimicrobial peptide (AMP), in combination with lysostaphin, an antistaphylococcal endope...

journal_title：International journal of antimicrobial agents

authors： Desbois AP,Gemmell CG,Coote PJ

更新日期：2010-06-01 00:00:00

abstract：:Fluoroquinolone (FQ) resistance is usually caused by point mutations within the quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and/or parE. However, little is known about the worldwide increase in FQ-resistant Escherichia coli or, more specifically, about the geographical distribution of QRDR mut...

journal_title：International journal of antimicrobial agents

authors： Uchida Y,Mochimaru T,Morokuma Y,Kiyosuke M,Fujise M,Eto F,Harada Y,Kadowaki M,Shimono N,Kang D

更新日期：2010-04-01 00:00:00

abstract：:Exposure of Aspergillus fumigatus to stressful antifungal therapies may result in decreased susceptibility. The aim of the present work was to evaluate the susceptibility to azole and non-azole antifungals of 159 isolates of A. fumigatus collected from cystic fibrosis (CF) patients receiving azole antifungal therapy. ...

journal_title：International journal of antimicrobial agents

authors： Amorim A,Guedes-Vaz L,Araujo R

更新日期：2010-04-01 00:00:00

abstract：:Synthesis and antibacterial screening of a homologous series of 3-dialkylaminophenothiazinium-7-norfloxacin conjugates was carried out alongside a corresponding series of symmetrical methylene blue derivatives. The norfloxacin conjugates maintained typical methylene blue derivative photoproperties, such as long wavele...

journal_title：International journal of antimicrobial agents

authors： Wainwright M,Shah A,Meegan K,Loughran C,Smith A,Valli N,Dempster N

更新日期：2010-04-01 00:00:00